Home Infant Reflux Main Treating Infant Reflux and Pediatric GERD Medications Lansoprazole or Prevacid

Lansoprazole (Prevacid) for Treating Infant Reflux and GERD

   
Rachel McMahon, B.Sc. Chem. Min. Sc.
January 2007
 

  
 

COMMON PRESCRIBING NAMES

US: prevacid, prevacid solutabs
CAN: prevacid, prevacid fastabs
UK: zoton, fastabs
AUS: zoton
GER: zoton, agopton, lanzor

PREPARATIONS

Capsules: 15 and 30 mg. Generally opened and placed in a small amount of apple juice or water and syringed to the child. Can also be sprinkled on food with a teaspoon of applesauce, cottage cheese, yogurt and strained pears only.

Powder for oral suspension: in 15 and 30 mg. Made into a liquid at home by adding water and then given via bottle, syringe or spoon.

Soluble tablet (solutab or fastab): 15 and 30mg tablets, which dissolve when placed under the tongue or held in the side of the cheek. Can be broken and given in smaller pieces, or dissolved with water in a syringe and given that way with water.

Compound: Made into a liquid form by a compounding pharmacy, which must then be stored in the refrigerator.

THINGS TO BE AWARE OF

  • If you split the solutab (with fingers is best to avoid crumbling) keep it in an airtight container and away from the sun and use this for the next dose. Break the solutab into quarters or smaller for younger children and make sure fully dissolved bit at a time to avoid choking.
  • With syringing a dissolved solution the beads may get stuck in a small syringe, so the larger the syringe (i.e. 20ml) the better to get the beads out, which is the active ingredient.
  • Compound generally only lasts 14 days, though some Drs and pharmacists will say 30 days, what is noticed that around the 14 day mark an increase of symptoms occur due to the product becoming unstable. Generally this is related to the effect of the flavorings added by pharmacies. Flavorings cause the PPI to become unstable and break down. Also many pharmacies do not add enough buffer to protect the drug from being eaten up by the stomach acid on the way down, especially in low doses.
  • Compound must be refrigerated, and for best results go to a proper compounding pharmacy.
  • Like all PPIs 30mins before food for maximum efficiency. The beads are the ingredient these should be swallowed whole and should not be crushed, split or chewed.
  • Never stop taking or administering a PPI abruptly always consult your doctor and note that in most cases, results are not immediate, on average it takes 10-14 days to notice a definite change, this depends on how severe the reflux and how much damage it is healing.
  • It has been found that children metabolize PPIs two to three times faster than middle age adults, and thus splitting the dose over 2 to 3 times a day gives better results.
  • In the past CaraCream and ChocoBase have been used to make a true at home suspension of prevacid, but it has since been taken off the market. The rights to the product were sold and they are no longer allowed to distribute and produce the CaraCream and ChocoBase commercially due to a non-compete agreement of Santarus Inc, which now makes zegerid. Both the CaraCream and ChocoBase, is still made in small quantities for children unable to take zegerid. Please contact the manufacturers.

STORAGE

Store at room temperature, 15-30C (59-86F). Keep away from moisture. Compound should be refrigerated.

PEDIATRIC DOSING

Lansoprazole is approved by the US Food and Drug Administration for pediatric use in children 12 months and over at a dose of: 15mg if under 30kg and 30mg if over 30kg.

In general though doctors tend to prescribe an initial dose of 15mg and this is upped to 30mg if need be. PPIs are less weight sensitive then other meds, so doses will depend on symptoms. A few Drs will prescribe lower doses, especially in babies, but 30mg is generally a max dose for children without further testing.

OTHER USES

Lansoprazole is used for treating ulcers of the stomach and duodenum, and Zollinger-Ellison Syndrome.

DRUG INTERACTIONS

The absorption of certain drugs may be affected by stomach acidity. It has been found that PPIs reduce stomach acid also reduce the absorption and concentration in blood of ketoconazole (Nizoral) so it has a reduced effectiveness and increase the absorption. It has also been found to and concentration in blood of digoxin (Lanoxin) hence an increased toxicity.

SIDE EFFECTS

Lansoprazole, like other PPIs is well-tolerated. The most common side effects are diarrhea, nausea, vomiting, constipation, rash and headaches. Dizziness, nervousness, abnormal heartbeat, muscle pain, weakness, leg cramps and water retention rarely occur.

 

 


 

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Site Last Modified: March 29, 2007
*Disclaimer: The information available on this website should not be used as a substitute for professional medical care for the prevention, diagnosis, or treatment of your child's reflux. Please consult with your child's doctor or pharmacist before trying any medication (prescription or OTC) or following any treatment plan mentioned. This information is provided only to help you be as informed as possible about your child's condition.
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